DNA and RNA random amplification polymorphism in 5-flurocytosine-resistant strains of Candida albicans from revul-vaginal candidasis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 69-72, 2005.
Article
in Zh
| WPRIM
| ID: wpr-353246
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the DNA genome and RNA expression in 5-flurocytosine-resistant strains of Candida albicans from vaginal candidasis.</p><p><b>METHODS</b>Sixteen strains of Candida albicans were selected from clinically diagnosed revul-vaginal candidasis. Eight 5-flurocytosine-sensitive isolates and 8 resistant isolates were examined by France Media FUNGUS sensitive test. DNA genome was detected with random amplification polymorph DNA. RNA expression was detected with random amplification polymorph RNA method.</p><p><b>RESULTS</b>There were no distinct differences between 5-flurocytosine-sensitive and resistant Candida albicans in DNA genome, while RNA expression showed significant differences between 5-flurocytosine-resistant and sensitive strains.</p><p><b>CONCLUSION</b>Clinical 5-flurocytosine-resistant strains of Candida albicans from revul-vaginal candidasis may be related to phenotype changes.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Candida albicans
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Candidiasis, Vulvovaginal
/
DNA, Fungal
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RNA, Fungal
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Random Amplified Polymorphic DNA Technique
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Drug Resistance, Fungal
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Flucytosine
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Genetics
/
Microbiology
Type of study:
Clinical_trials
Limits:
Adolescent
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Adult
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Female
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Humans
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2005
Type:
Article