Induction of HSF1 expression and sporadic colorectal cancer / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 390-394, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-353297
ABSTRACT
<p><b>OBJECTIVE</b>To explore the activation of the signal transduction pathways related with the carcinogenesis of sporadic colon cancers.</p><p><b>METHODS</b>A gene microarray monitoring activation of 8 signal transduction pathways (PathwayFinder GEArray) was used to screen the differentially expressed genes between colorectal cancer and normal colon tissue. The differentially expressed genes were further analyzed by RT-PCR, using RNA extracted from cancer tissue and matched normal colon mucosa of 35 patients with colorectal cancer.</p><p><b>RESULTS</b>The expression of hsf1, hsf27 and inos was increased in colon cancer compared with normal colon mucosa using PathwayFinder GEArray. The RT-PCR results showed that the expression of hsf1 was detected in 86% of patients(30/35)and the expression of inos detected in 63% patients(22/35).</p><p><b>CONCLUSION</b>Hsf1 induces heat shock stress signaling pathway, which might play a role in the carcinogenesis of sporadic colorectal cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Transcription Factors
/
Colorectal Neoplasms
/
Signal Transduction
/
Gene Expression Regulation, Neoplastic
/
Reverse Transcriptase Polymerase Chain Reaction
/
Tumor Suppressor Proteins
/
Intracellular Signaling Peptides and Proteins
/
DNA-Binding Proteins
/
Heat Shock Transcription Factors
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2004
Type:
Article
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