Modulating drug loading and release profile of beta-cyclodextrin polymers by means of cross-linked degree / 药学学报
Acta Pharmaceutica Sinica
;
(12): 221-226, 2011.
Article
in English
| WPRIM
| ID: wpr-353319
ABSTRACT
The purpose of the present study is to use beta-cyclodextrin polymers (beta-CDP) with different cross-linked degree (CLD) to form inclusion complexes with ibuprofen and examine the effects of structural and compositional factors of beta-CDP on its drug loading and release behaviors. A series of beta-CDP with different CLD were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and 13C NMR spectrum. The beta-CDP was systemically characterized for the relation between the CLD of beta-CDP and the drug loading and release as well. The results of FT-IR and 13C NMR showed that similar peak-shaped vibration of beta-CDP and beta-CD implies that the polymer keeps the original characteristic structure of beta-CD. The CLD of the beta-CDP played a critical role in the drug loading and release, increasing the CLD resulted in reduction of drug loading, but increase in drug release.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymers
/
Solubility
/
Carbon Isotopes
/
Drug Carriers
/
Pharmaceutical Preparations
/
Magnetic Resonance Spectroscopy
/
Chemistry
/
Ibuprofen
/
Drug Delivery Systems
/
Spectroscopy, Fourier Transform Infrared
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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