Synthesis of thienopyridine derivatives and its anti-platelet activity in vivo / 药学学报
Acta Pharmaceutica Sinica
;
(12): 70-74, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-353328
ABSTRACT
To explore novel ADP receptor inhibitors with anti-thrombotic activity, eighteen compounds were synthesized and their structures were confirmed by 1H NMR and MS. The results showed that the activity of compound C1 was superior to ticlopidine in platelet aggregation inhibition tests in vivo and worthy for further investigation. Compounds A4, B2, C4 and C7 possessed moderate platelet aggregation inhibitory activities.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Platelet Aggregation Inhibitors
/
Molecular Structure
/
Random Allocation
/
Chemistry
/
Platelet Aggregation
/
Rats, Wistar
/
Thienopyridines
/
Purinergic P2Y Receptor Antagonists
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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