The role of ADME evaluation in translation research of innovative drug / 药学学报
Acta Pharmaceutica Sinica
;
(12): 19-29, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-353335
ABSTRACT
New Chemical Entities (NCEs) development is a systematic long-term project that involves multiple disciplines. The translation research will help to build an advanced R&D system from the basic laboratory research, preclinical studies and clinical evaluation to clinical application of drug, for the purpose of shortening the R&D cycle and accelerate the launch of new drugs. In new drug R&D and its clinical application, drug disposition (absorption, distribution, metabolism, excretion, ADME) properties are important criteria for assessing drug-likeness of candidates. ADME evaluation of NCEs plays an important role in the translation research throughout innovative drug R&D process. Therefore, ADME evaluation at the early stage of drug design and development will be helpful to improve the success rate and reduce costs, and further access to safe, effective drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biological Transport
/
Pharmacokinetics
/
Pharmaceutical Preparations
/
Tissue Distribution
/
Drug Design
/
Chemistry
/
Drug Evaluation, Preclinical
/
Absorption
/
Translational Research, Biomedical
/
Metabolism
Type of study:
Prognostic study
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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