Synthesis and antiproliferative activities of novel 5'-Schiff-base group substituted psoralen derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 64-69, 2011.
Article
in En
| WPRIM
| ID: wpr-353340
Responsible library:
WPRO
ABSTRACT
It was found that psoralen derivative could perform a Friedel-Crafts acylation smoothly with acetic anhydride to give 5'-acetylpsoralen in a 73% yield. In the presence of boron trifluoride etherate, 5'-acetylpsoralen reacted with both aromatic amines and aliphatic amine smoothly to afford 5'-Schiff-base group substituted psoralen derivatives in 72%-92% yields. The novel synthetic method has the advantages of cheap materials, mild reaction conditions, good yields and high regioselectivity in the Friedel-Crafts acylation. Cell viability assay by MTT demonstrates that some of the psoralen derivatives 6 have antiproliferative activities.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Furocoumarins
/
Schiff Bases
/
Boranes
/
Acylation
/
Molecular Structure
/
Chemistry
/
Cell Line, Tumor
/
Cell Proliferation
Limits:
Humans
Language:
En
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article