Design, synthesis and in vitro activity of glycinamide-bearing compounds as DPP-IV inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1379-1384, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-353350
ABSTRACT
To research the structure-activity relationship (SAR) of glycinamide-bearing compounds that used as inhibitors of dipeptidyl peptidase IV (DPP-IV), P32/98 and compound A were chosen as the leading compounds, heterocycles containing nitrogen atom were introduced to form amide, and different residues on a-position of carbonyl were designed. The nineteen designed compounds were synthesized by a simple route and were evaluated as inhibitors of DPP-IV. All of the structures were characterized by 1H NMR and HRMS. The preliminary SAR result was obtained.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Piperazines
/
Structure-Activity Relationship
/
Magnetic Resonance Spectroscopy
/
Drug Design
/
Molecular Structure
/
Chemistry
/
Dipeptidyl Peptidase 4
/
Dipeptidyl-Peptidase IV Inhibitors
/
Glycine
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article
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