Advance in the study of poly(lactide-co-glycolide) nano/microparticles as gene vector / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1346-1353, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-353355
ABSTRACT
Biodegradable nano/microparticles of poly(D, L-lactide-co-glycolide) (PLGA) is a novel non-viral gene vector, which has many advantages, such as safety, non-immunogenicity, easy of large-scale preparation and well load-capability. Therefore, more and more attentions and researches have been paid on its application. Especially, PLGA has shown enormous potential application value and space in the field of plasmid DNA (pDNA) delivery system. On the basis of the current situation of PLGA nano/microparticles for pDNA delivery, this paper focused on summarizing the current preparation approaches and surface modified methods of PLGA particle, furthermore showing its application in gene therapy and genetic vaccine delivery. These showed that PLGA nano/microparticles have extensive prospect in the development of controlled gene delivery system.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Plasmids
/
Polyglycolic Acid
/
Polymers
/
Drug Carriers
/
Chemistry
/
Drug Delivery Systems
/
Gene Transfer Techniques
/
Lactic Acid
/
Emulsions
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article
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