Monomeric indole alkaloids from the aerial parts of Catharanthus roseus / 药学学报
Acta Pharmaceutica Sinica
;
(12): 471-474, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-353373
ABSTRACT
Catharanthus roseus (L.) G. Don is a plant of the Catharanthus genus of Apocynaceae which has been reported to have therapeutic effects of detoxication and anticancer. In order to further study the alkaloid constituents of C. roseus, the aerial parts of the plant were extracted with 95% EtOH, and then treated with 2% H2SO4 and NH3H2O to obtain total alkaloids. The total alkaloids were separated and purified by column chromatography over silica gel and prepared by high performance liquid chromatography (HPLC). Their structures were elucidated on the basis of physicochemical properties and spectral data. A new alkaloid together with five known compounds were isolated and identified as vindolinine B (1), lochnericine (2), horhammericine (3), vindorosine (4), vindoline (5), and coronaridine (6). Compound 1 is a new compound and named as vindolinine B.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Vinblastine
/
Molecular Structure
/
Chemistry
/
Catharanthus
/
Indole Alkaloids
/
Plant Components, Aerial
/
Ibogaine
/
Antineoplastic Agents, Phytogenic
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article
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