Quantitative prediction of in vivo drug-drug interactions based on in vitro inhibition or/and induction data for CYP3A4 / 药学学报
Acta Pharmaceutica Sinica
;
(12): 952-959, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-353399
ABSTRACT
Inhibition or/and induction of CYP3A4 are the major mechanisms underlying the common clinical drug-drug interactions, which has been gained attention in new drug discovery and development as well as clinical practice. Quantitative prediction of drug-drug interactions at the early stage of drug development is advantageous for reducing the cost and duration of development and providing more information for the later clinical studies. The review summarizes the update progress on quantitative prediction of in vivo drug-drug interactions derived from models based on in vitro inhibition or/and induction for CYP3A4.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Pharmaceutical Preparations
/
Area Under Curve
/
Drug Interactions
/
Enzyme Inhibitors
/
Cytochrome P-450 CYP3A
/
Cytochrome P-450 CYP3A Inhibitors
/
Intestines
/
Liver
/
Metabolism
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article
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