The biotransformation of kaempferitrin by human intestinal flora / 药学学报

ABSTRACT

<p><b>AIM</b>To study the biotransformation of kaempferitrin, a major chemical principle of the fruits of Siraitia grosvenori (Swingle) C. Jeffery, with human intestinal flora.</p><p><b>METHODS</b>The kaempferitrin was incubated with human intestinal flora. The biotransformation products were isolated and purified by chromatographic methods and the structures were determined by spectroscopic techniques.</p><p><b>RESULTS</b>Kaempferitrin was converted into kaempferol 3-O-alpha-L-rhamnoside (afzelin, I) , kaempferol 7-O-alpha-L-rhamnoside (II), kaempferol (III) and p-hydroxybenzoic acid (IV) by human intestinal flora. rhamnoside (II), kaempferol (III) and p-hydroxybenzoic acid (IV) by human intestinal flora.</p><p><b>CONCLUSION</b>The structure of kaempferitrin can be biotransformatedly converted by human intestinal flora.</p>