Effects of intranasal administration of nimodipine on cerebral hemodynamics of dogs / 药学学报

ABSTRACT

<p><b>AIM</b>To investigate the effect of nimodipine (NM) on cerebral blood flow (CBF) in dogs following intranasal administration.</p><p><b>METHODS</b>NM solution was administered intranasally, intravenously (i.v.), and orally to dogs and the change of CBF was determined by using electromagnetic blood flowmeter. MFLab experimental program was applied to monitor the experimental process and analyze data.</p><p><b>RESULTS</b>CBF markedly increased after iv and intranasal application, while large variance was observed after oral dosing. CBF in dogs after three administrations increased by 26.4%, 28.0% and 8.5%, respectively, compared with that of baseline. Following intranasal administration, the onset of action was slightly slower than that after iv injection [(5 +/- 4) min vs (2.2 +/- 1.2) min], however the duration of improvement was the longest [ (25 +/- 17) min].</p><p><b>CONCLUSION</b>Intranasal delivery for NM can be a promising alternative to parenteral or oral administration.</p>