Tissue distribution and excretion of bromotetrandrine in rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 453-456, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-353436
ABSTRACT
<p><b>AIM</b>To study the tissue distribution and excretion of bromotetrandrine (W198) in rats.</p><p><b>METHODS</b>The concentrations of W198 in biological samples were determined by an HPLC method with UV detection.</p><p><b>RESULTS</b>After a single i.v. dose of 20 mg x kg(-1) W198 in rats, the parent drug concentrations in tissues were higher than those in blood at the same time. Parent drug was mainly distributed in lung, kidney, heart and liver, the peak levels were attained at 0.25 h and decreasing at 2 h after dosing in most tissues. After a single iv dose of 20 mg x kg(-1) W198 in rats, the excretion of the parent drug in urine, feces and bile amounted to 0. 150%, 2.1% and 0.063% of the dose, respectively.</p><p><b>CONCLUSION</b>W198 was mostly distributed in lung. The parent drug excretion was less than 3% via urine, feces and bile.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urine
/
Bile
/
Pharmacokinetics
/
Tissue Distribution
/
Molecular Structure
/
Chemistry
/
Rats, Wistar
/
Benzylisoquinolines
/
Feces
/
Kidney
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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