Effects of ferulic acid on E-selectin expression in activated endothelial cell and leukocyte-endothelial cell adhesion / 药学学报
Acta Pharmaceutica Sinica
;
(12): 410-413, 2005.
Article
in English
| WPRIM
| ID: wpr-353446
ABSTRACT
<p><b>AIM</b>To study the effects of ferulic acid (FA) on E-selectin expression in human umbilical vein endothelial cells (HUVECs) activated by lipopolysaccharide and leukocyte-endothelial cell adhesion.</p><p><b>METHODS</b>The effects of FA on E-selectin and E-selectin mRNA expression were determined by flow cytometry and reverse transcription polymerase chain reaction. The effect of FA on HL60-HUVEC adhesion was evaluated with the method of staining the cells by Rose Bengal.</p><p><b>RESULTS</b>The expression of E-selectin and E-selectin mRNA were down regulated by FA (0.62 and 0.41 mmol x L(-1), respectively). HL60 cells adhered to activated HUVECs were also reduced by FA (0.62 and 0.41 mmol x L(-1), respectively).</p><p><b>CONCLUSION</b>FA can inhibit the expression of E-selectin and E-selectin mRNA and HL60-HUVEC adhesion. This may contribute to its protective effect against ischemia-reperfusion injury.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Umbilical Veins
/
RNA, Messenger
/
Cell Adhesion
/
Cells, Cultured
/
HL-60 Cells
/
E-Selectin
/
Coumaric Acids
/
Cell Biology
Limits:
Humans
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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