The tissue distribution in mice and pharmacokinetics in rabbits of oridonin-solid lipid nanoparticles / 药学学报
Acta Pharmaceutica Sinica
;
(12): 573-576, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-353470
ABSTRACT
<p><b>AIM</b>To investigate the tissue distribution and pharmacokinetics of oridonin-solid lipid nanoparticles in animals.</p><p><b>METHODS</b>HPLC method was established to determine the concentration of oridonin in serum of rabbits and in different tissues of mice. The results after tail iv administration of oridonin and oridonin solid lipid nanoparticles were compared.</p><p><b>RESULTS</b>The relative tissue content of oridonin of solid lipid nanoparticles in the liver, spleen, lung, heart and kidney were 4.25%, 3.44%, 1.19%, 0.52% and 0.60%, respectively. The concentration-time curves of oridonin and oridonin solid lipid nanoparticles were both fitted to the three-compartment model. T(1/2)pi = 0.087 h, T(1/2)alpha = 1.65 h, T(1/2)beta = 32.36 h, V(C) = 0.66 mL.kg(-1).</p><p><b>CONCLUSION</b>Solid lipid nanoparticles could increase the hepatic and lienic targeting efficiency of oridonin in mice and improve its bioavailability. Solid lipid nanoparticles were helpful for oridonin to reach a long circulation time and were hopeful to be its novel drug carrier.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Spleen
/
Drug Carriers
/
Pharmacokinetics
/
Tissue Distribution
/
Chemistry
/
Drug Delivery Systems
/
Area Under Curve
/
Isodon
/
Diterpenes, Kaurane
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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