Synthesis and antibacterial activity of 3-(5-substituted phenyl-1,3,4 oxadiazole-2-yl-methylenethio)-5-pyridin-3-yl-1,2,4 triazole-4-yl-amines / 药学学报
Acta Pharmaceutica Sinica
;
(12): 337-339, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-353501
ABSTRACT
<p><b>AIM</b>To study on synthesis and antibacterial activity evaluation of polyheterocycles.</p><p><b>METHODS</b>The condensation of 4-amino-3-pyridin-3-yl-4H-[1,2,4] triazole-5-thiol with 2-chloromethyl-5-substituted phenyl-[1,3,4] oxadiazoles gave the corresponding title heterocycle amines, and the in vitro antibacterial activity was primarily evaluated by the method of cup-plate diffusion solution.</p><p><b>RESULTS</b>Twelve novel compounds were synthesized, and their structures were confirmed by IR, 1H NMR, MS and element analysis. Biological screening results demonstrated that most of the compounds prepared showed good antibacterial activity.</p><p><b>CONCLUSION</b>Oxadiazoles incorporting pyridyl triazole ring may be a pharmacophor structure in the molecule for developing antibacterial candidate drugs.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxadiazoles
/
Pharmacology
/
Proteus vulgaris
/
Staphylococcus aureus
/
Triazoles
/
Chemistry
/
Escherichia coli
/
Anti-Bacterial Agents
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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