Immune tolerance induction in a severe hemophilia A patient with inhibitor / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 577-580, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-353614
ABSTRACT
<p><b>OBJECTIVE</b>To explore the immune tolerance induction (ITI) in a severe hemophilia A patient with inhibitor, and to improve the therapeutic efficacy for patient.</p><p><b>METHODS</b>The FVIIIC was assayed by one-stage method and FVIII antibody by Bethesda method. Mutation screening of FVIII gene intron 22 inversion was performed using LD-PCR.</p><p><b>RESULTS</b>FVIII gene intron 22 inversion was detected in this patient. Clinical tolerance to FVIII was successfully induced after administration of the ITI regimen combined with immunosuppression. A fall of inhibitor titer from 8 BU to 0 BU after treatment for 3 months, and in vivo FVIII recovery (> 66%) was normalized. The patient had no bleeding episode in the following 6 months.</p><p><b>CONCLUSION</b>This is the first case report on successful immune tolerance induction therapy in Chinese hemophilia A patient. ITI is the most effective therapy for hemophilia A with inhibitor.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
Factor VIII
/
Immunosuppression Therapy
/
Allergy and Immunology
/
Genetics
/
Hemophilia A
/
Immune Tolerance
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2010
Type:
Article
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