Treatment of primary systemic amyloidosis with the combination of bortezomib and dexamethasone / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 319-322, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-353617
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and feasibility of bortezomib plus dexamethasone (BD) in patients with primary systemic (AL) amyloidosis.</p><p><b>METHODS</b>Eleven AL amyloidosis patients, including four relapsed or progressed after previous therapies and 7 newly diagnosed were treated with BD. Ten patients had two or more organs involved. Precursor protein analysis showed that 1 was κ light chain, 9 λ light chain; 5 patients with positive immunofixation including 1 IgG κ, 3 IgG λ and 1 IgA λ. BD was administered according to standard two-week schedule.</p><p><b>RESULTS</b>Eight patients were evaluable, the median number of treatment cycles was 3 (range 1 - 6). Median follow-up duration was 6 months. At least one affected organ response was observed in six patients and median time to organ response was 2 months. Three patients progressed and two of them died. Toxicities were mainly diarrhea, thrombocytopenia, peripheral neuropathy, fatigue and herpes zoster, and 7 evaluable patients who had toxicities were adjusted dosage and 2 of them interrupted therapy. Epilepsia, paralytic ileus, acute cardiac dysfunction, and postural hypotention were occurred in 3 inevaluble patients.</p><p><b>CONCLUSION</b>Bortezomib plus dexamethasone is effective in AL amyloidosis. Adverse events are common, and in some patients are severe.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Boronic Acids
/
Dexamethasone
/
Therapeutic Uses
/
Drug Therapy
/
Bortezomib
/
Amyloidosis
/
Multiple Myeloma
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2010
Type:
Article
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