Analysis of long-term outcomes and risk factors in patients undergoing simultaneous resection of synchronous colorectal liver metastasis / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 925-929, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-353808
ABSTRACT
<p><b>OBJECTIVE</b>To analyze long-term outcomes and related risk factors in patients undergoing simultaneous resection of synchronous colorectal liver metastasis.</p><p><b>METHODS</b>Clinicopathological, short- and long-term outcome data of 154 consecutive synchronous colorectal liver metastasis patients who underwent simultaneous resection between July 2003 and July 2013 were collected and analyzed with Cox multivariate methods retrospectively.</p><p><b>RESULTS</b>No perioperative death was found. A total of 46 patients (29.9%) had complications, which were all successfully treated medically or by percutaneous drainage. The 5-year overall survival rate was 46%, and the 5-year disease-free survival rate was 35%. Four factors were found to be independent predictors of poor overall survival by multivariate analysis:
positive lymph node status (P=0.000), number of metastasis focus (≥4) (P=0.017), bilobar liver metastasis distribution (P=0.004) and non-R0 resection of liver metastasis (P=0.001). Three factors were found to be independent predictors of poor disease-free survival by multivariateanalysis:
positive lymph node status (P=0.031), bilobar liver metastasis distribution (P=0.001) and extrahepatic metastases (P=0.020).</p><p><b>CONCLUSIONS</b>Simultaneous resection of synchronous colorectal liver metastasis is safe and its short- and long-term outcomes are quite good. Positive lymph node status, number of metastasis focus (≥4), bilobar liver metastasis distribution, non-R0 resection of liver metastasis and extrahepatic metastasis are risk factors of poor long-term prognosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
General Surgery
/
Colorectal Neoplasms
/
Multivariate Analysis
/
Survival Rate
/
Retrospective Studies
/
Risk Factors
/
Disease-Free Survival
/
Hepatectomy
/
Liver Neoplasms
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2015
Type:
Article
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