Role of serum 25-hydroxyvitamin D in the diagnosis of vitamin D deficiency rickets / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 767-770, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-353869
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of serum 25-hydroxyvitamin D in the early diagnosis of vitamin D deficiency rickets.</p><p><b>METHODS</b>Concentrations of serum 25(OH)D, calcium, phosphorus and alkaline phosphatase were measured in normal control (n=73), suspected rickets (n=45) and confirmed rickets groups (n=65). Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of serum 25(OH)D for rickets.</p><p><b>RESULTS</b>Serum 25(OH)D levels in the suspected and confirmed rickets groups were 83±30 and 72±31 nmol/L respectively, which was lower than in the normal control group (112±37 nmol/L) (P<0.01). There was no significant difference between the suspected and confirmed rickets groups (P>0.05). Vitamin D deficiency rates in the suspected and confirmed rickets groups were higher than in the control group (P<0.01). The ROC curve area of serum 25(OH)D for the diagnosis of rickets was 0.760 (95%CI 0.692-0.820, P<0.01), and the optimal operating point was 90.70 nmol/L (sensitivity 68.49%, specificity 72.73%). There was no significant difference in levels of calcium, phosphorus and alkaline phosphatase between the three groups (P>0.05).</p><p><b>CONCLUSIONS</b>Serum 25(OH)D levels in infants with suspected and confirmed rickets are significantly reduced and this may reflect vitamin D deficiency . Therefore, it may be useful to check serum 25(OH)D levels in screening for rickets.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rickets
/
Vitamin D
/
Blood
/
ROC Curve
/
Diagnosis
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2012
Type:
Article
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