Association between platelet-activating factor acetylhydrolase gene polymorphism and intracranial hemorrhage in preterm infants / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 612-615, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-353906
ABSTRACT
<p><b>OBJECTIVE</b>To explore whether Val279Phe single nucleotide polymorphisms (SNPs) in the 9th exon of platelet-activating factor acetylhydrolase (PAF-AH) are associated with intracranial hemorrhage in preterm infants.</p><p><b>METHODS</b>A case-control study was performed. Polymerase chain reaction (PCR) was used to test genotype and allele frequencies of the 9th exon Val279Phe SNPs of PAF-AH in 58 preterm infants with intracranial hemorrhage (hemorrhage group) and 65 preterm infants without intracranial hemorrhage (control group).</p><p><b>RESULTS</b>There were significant differences in genotype frequency of Val279Phe SNPs in the 9th exon of PAF-AH between the hemorrhage and control groups (P<0.05). Frequency of normal genotype in the hemorrhage group (63.8%) was significantly lower than in the control group (81.5%). In contrast, frequency of heterozygous genotype (34.5%) in the hemorrhage group was significantly higher than in control group (16.9%). There were also significant differences in allele frequency of Val279Phe SNPs in the 9th exon of PAF-AH between the two groups (P<0.05). T allele frequency in the hemorrhage group (19.0%) was significantly higher than in the control group (10.0%).</p><p><b>CONCLUSIONS</b>Val279Phe SNPs in the 9th exon of PAF-AH may be associated with intracranial hemorrhage in preterm infants.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Infant, Premature
/
Intracranial Hemorrhages
/
Polymorphism, Single Nucleotide
/
1-Alkyl-2-acetylglycerophosphocholine Esterase
/
Genetics
Type of study:
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2012
Type:
Article
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