Serratia marcescens vaccine in the treatment of malignant pleural effusion / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 188-190, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-354038
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and toxicity of Serratia marcescens (S311) vaccine in the treatment of malignant pleural effusion.</p><p><b>METHODS</b>Thirty-four patients with malignant pleural effusion were given S311 as intrapleural injection with a dose of 10(9) U (0.32 mg) on D 1, 8 and 15, and observed for four weeks.</p><p><b>RESULTS</b>The overall response rate (CR + PR) was 97.1% (CR in 12 patients and PR in 21 patients). The systemic toxicity was mild, including fever (82.4%), pleuritic pain (50.7%), nansea (26.5%), dyspnea (17.5%) and chills (5.9%).</p><p><b>CONCLUSION</b>Serratia marcescens vaccine is effective for malignant pleural effusion, with tolerable toxic effects. Further study is warranted.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pleural Effusion
/
Serratia marcescens
/
Time Factors
/
Chest Pain
/
Bacterial Vaccines
/
Treatment Outcome
/
Therapeutic Uses
/
Dose-Response Relationship, Drug
/
Drug Therapy
/
Allergy and Immunology
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2002
Type:
Article
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