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Serratia marcescens vaccine in the treatment of malignant pleural effusion / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 188-190, 2002.
Article in Chinese | WPRIM | ID: wpr-354038
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and toxicity of Serratia marcescens (S311) vaccine in the treatment of malignant pleural effusion.</p><p><b>METHODS</b>Thirty-four patients with malignant pleural effusion were given S311 as intrapleural injection with a dose of 10(9) U (0.32 mg) on D 1, 8 and 15, and observed for four weeks.</p><p><b>RESULTS</b>The overall response rate (CR + PR) was 97.1% (CR in 12 patients and PR in 21 patients). The systemic toxicity was mild, including fever (82.4%), pleuritic pain (50.7%), nansea (26.5%), dyspnea (17.5%) and chills (5.9%).</p><p><b>CONCLUSION</b>Serratia marcescens vaccine is effective for malignant pleural effusion, with tolerable toxic effects. Further study is warranted.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pleural Effusion / Serratia marcescens / Time Factors / Chest Pain / Bacterial Vaccines / Treatment Outcome / Therapeutic Uses / Dose-Response Relationship, Drug / Drug Therapy / Allergy and Immunology Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pleural Effusion / Serratia marcescens / Time Factors / Chest Pain / Bacterial Vaccines / Treatment Outcome / Therapeutic Uses / Dose-Response Relationship, Drug / Drug Therapy / Allergy and Immunology Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2002 Type: Article