Plerosis of cDNA array of normal human nasopharyngeal tissue and nasopharyngeal carcinoma / 中华肿瘤杂志

ABSTRACT

<p><b>OBJECTIVE</b>To compare gene expression gene profile of nasopharyngeal carcinoma (NPC) tissue with that of normal nasopharyngeal tissues by cDNA array and to discuss possible functions of DNA repair-related genes in NPC tissue.</p><p><b>METHODS</b>After hybridization of atlas human cancer cDNA expression array 7742 - 1, atlas hybridization results were analyzed by Atlas Image 1.01 a software package. Using RT-PCR was used to confirm the results.</p><p><b>RESULTS</b>Of 63 differentially expressed genes in quadrangle C including DNA damage response, repair & recombination-related genes, 6 DNA repair-related genes were up-regulated, 12 were down-regulated.</p><p><b>CONCLUSION</b>DNA repair-related genes may be involved in patho-physiological process of nasopharyngeal carcinoma.</p>