The Value of Elastic Modulus Index as a Novel Surrogate Marker for Cardiovascular Risk Stratification by Dimensional Speckle-Tracking Carotid Ultrasonography
Journal of Cardiovascular Ultrasound
;
: 215-222, 2016.
Article
in English
| WPRIM
| ID: wpr-35407
ABSTRACT
BACKGROUND:
Carotid intima media thickness (CIMT) and the presence of carotid plaque have been used for risk stratification of cardiovascular disease (CVD). To date, however, the association between multi-directional functional properties of carotid artery and CVD has not been fully elucidated. We sought to explore the multi-directional mechanics of the carotid artery in relation to cardiovascular risk.METHODS:
Four hundred one patients who underwent carotid ultrasound were enrolled between January 2010 and April 2013. A high risk of CVD was defined as more than 20% of 10-year risk based on the Framingham risk score. Using a speckle-tracking technique, the longitudinal and radial movements were analyzed in the B-mode images. Peak longitudinal and radial displacements, strain and strain rate were also measured. Beta stiffness and elastic modulus index were calculated from the radial measurements.RESULTS:
Of the overall sample, 13% (52) of patients comprised the high-risk group. In multivariate logistic regression, CIMT and elastic modulus index were independently associated with a high-risk of CVD {odds ratio (OR) 1.810 [95% confidence interval (CI) 1.249–2.622] and OR 1.767 (95% CI 1.177–2.652); p = 0.002, 0.006, respectively}. The combination of CIMT and elastic modulus index correlated with a high-risk of CVD more so than CIMT alone.CONCLUSION:
The elastic modulus index of the carotid artery might serve as a novel surrogate marker of high-risk CVD. Measurement of the multi-directional mechanics of the carotid artery using the speckle tracking technique has potential for providing further information over conventional B-mode ultrasound for stratification of CVD risk.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biomarkers
/
Cardiovascular Diseases
/
Carotid Arteries
/
Logistic Models
/
Ultrasonography
/
Mechanics
/
Elastic Modulus
/
Carotid Intima-Media Thickness
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Cardiovascular Ultrasound
Year:
2016
Type:
Article
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