Chemical constituents from the roots of Pithecellobium lucidum and their cytotoxic activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1769-1771, 2011.
Article
in Zh
| WPRIM
| ID: wpr-354127
Responsible library:
WPRO
ABSTRACT
Six compounds were isolated from the roots of Pithecellobium lucidum by various chromatograhic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as julibroside A2 (1), 3-[ (2-acetamido-2-deoxy-beta-D-glucopyranosyl) oxy] -16alpha-hydroxyolean-12-en-28-oic acid (2), galloyl acid (3), ethyl gallate (4), (+)-catechin (5), (-)-gallocatechin gallate (6) on the basis of spectrascopic data analysis. Compounds 1-6 were isolated from Pithecellobium lucidum for the first time. Compound 2 showed selective cytoxic activity against the human cell lines A2780 with an IC50 value of 1.72 micromol x L(-1).
Full text:
1
Index:
WPRIM
Main subject:
Oleanolic Acid
/
Plants, Medicinal
/
Saponins
/
Triterpenes
/
Plant Extracts
/
Catechin
/
Cell Line
/
Chemistry
/
Plant Roots
/
Inhibitory Concentration 50
Limits:
Humans
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article