Influence of penetration enhancers on in vitro transdermal permeation of L-tethrahydropalmatine / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1729-1732, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-354134
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of different penetration enhancers on the in vitro transdermal permeation of 1-tethrahydropalmatine (L-THP) through rat skin.</p><p><b>METHOD</b>Both natural and chemical synthesis penetration enhancers were applied singly or jointly to investigate the skin permeation rates of l-THP. The skin permeation profiles were evaluated by Valian-Chien permeation cells with isolated rat skin. HPLC-UV method was established to determine the concentration of l-THP in samples.</p><p><b>RESULT</b>As chemical synthesis penetration enhancer was used alone, 8% azone was observed to be the optimal penetration enhancer with the maximal penetration rate of 21.153 microg x cm(-20 x h(-1). Although 2% menthol crystal or 5% eucalyptus oil was effective as a natural penetration enhancer when used alone, the average penetration rate reached only half of that of 8% azone. The penetration potency of either menthol oil or menthol crystal combined with 8% azone was more effective than that of azone alone (P < 0.05).</p><p><b>CONCLUSION</b>Either menthol oil or menthol crystal combined with 8% azone is effective on transdermal penetration of l-THP in vitro. There is significant synergistic effect when natural penetration enhancers combined with chemical synthesis penetration enhancers.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Pharmacology
/
Skin
/
Skin Absorption
/
Azepines
/
Berberine Alkaloids
/
Administration, Cutaneous
/
Oils, Volatile
/
Pharmacokinetics
/
Chemistry
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article
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