Preparation and characterization of niosomes of Semen Strychni alkaloids extract / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1955-1958, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-354154
ABSTRACT
<p><b>OBJECTIVE</b>To prepare a noisome formulation of Semen Strychni alkaloids extract with high encapsulation efficiency.</p><p><b>METHOD</b>S. Strychni alkaloids were encapsulated into niosomes by pH gradient loading method. The factors influencing on the encapsulation efficiency were investigated, and formulation and preparation process of niosomes were optimised and validated.</p><p><b>RESULT</b>When the drug to lipid weight ratio was under 1 10, pH gradient in buffer solution of citric acid at 50 degrees C was more than 4.0, the niosomes (mean diameter 179.2 nm and Zeta potential -25.41 mV) were formed with encapsulation efficiency of over 86.9%.</p><p><b>CONCLUSION</b>The pH gradient loading method was reliable for preparing niosomes of Semen Strychni alkaloids extract.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Temperature
/
Capsules
/
Drugs, Chinese Herbal
/
Chemistry
/
Strychnos nux-vomica
/
Drug Compounding
/
Alkaloids
/
Hydrogen-Ion Concentration
/
Liposomes
/
Methods
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article
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