Experimental model of histamine-induced anaphylactoid reaction on beagle dogs / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1842-1844, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-354177
ABSTRACT
<p><b>OBJECTIVE</b>To establish animal model of histamine-induced anaphylactoid reactions on Beagle dogs through intravenous injection of histamine phosphate injection.</p><p><b>METHOD</b>Anaphylactoid reactions was determined according to the changes of praxiology and blood pressure of Beagle dogs after one intravenous injection of histamine phosphate injection.</p><p><b>RESULT</b>It showed that typical anaphylactoid reactions be caused by histamine phosphate injection on Beagle dogs, and the response of the high-dose group was more obvious than that of the low-dose group.</p><p><b>CONCLUSION</b>Intravenous injection of histamine phosphate injection could simulate Beagle dogs to bring typical clinical anaphylactoid reaction, that could be used as a sensitive animal model to evaluate anaphylactoid reaction of traditional Chinese medicine injections (TCMIs) in the pre-clinical experiments of both TCMIs and their composition.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Histamine
/
Disease Models, Animal
/
Dose-Response Relationship, Drug
/
Anaphylaxis
/
Injections, Intravenous
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article
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