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Experimental model of histamine-induced anaphylactoid reaction on beagle dogs / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1842-1844, 2011.
Article in Chinese | WPRIM | ID: wpr-354177
ABSTRACT
<p><b>OBJECTIVE</b>To establish animal model of histamine-induced anaphylactoid reactions on Beagle dogs through intravenous injection of histamine phosphate injection.</p><p><b>METHOD</b>Anaphylactoid reactions was determined according to the changes of praxiology and blood pressure of Beagle dogs after one intravenous injection of histamine phosphate injection.</p><p><b>RESULT</b>It showed that typical anaphylactoid reactions be caused by histamine phosphate injection on Beagle dogs, and the response of the high-dose group was more obvious than that of the low-dose group.</p><p><b>CONCLUSION</b>Intravenous injection of histamine phosphate injection could simulate Beagle dogs to bring typical clinical anaphylactoid reaction, that could be used as a sensitive animal model to evaluate anaphylactoid reaction of traditional Chinese medicine injections (TCMIs) in the pre-clinical experiments of both TCMIs and their composition.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Drugs, Chinese Herbal / Histamine / Disease Models, Animal / Dose-Response Relationship, Drug / Anaphylaxis / Injections, Intravenous Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Drugs, Chinese Herbal / Histamine / Disease Models, Animal / Dose-Response Relationship, Drug / Anaphylaxis / Injections, Intravenous Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article