Structure charateristics of mitoxantrone transforsomes / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 555-559, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-354251
ABSTRACT
This study sought to clarify the molecular location and the interaction between mitoxantrone and mitoxantrone transforsomes. The anthraquinone of mitoxantrone, a heterocyclic ring that intercalates in the lipid of bilayer, was determined by UV-spectrophotometry and electron probes scan microscopy. Two aminoethylamino side-chains of the drugs fit to the phosphates of lecithin were determined by 8-value, thus the interaction with lecithin was substantiated. Differential scanning calorimetry confirmed that mitoxantrone has remarkable stabilizing effect on the mitoxantrone transforsomes membrane. The mitoxantrone binds tightly to lecithin. So a high degree of encapsulation efficiency and the sustained-release character of mitoxantrone transforsomes are verified.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spectrophotometry
/
Calorimetry, Differential Scanning
/
Chemistry
/
Anthraquinones
/
Mitoxantrone
/
Delayed-Action Preparations
/
Lecithins
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2005
Type:
Article
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