Synthesis of a bio-active bone-matrix material and study of the cellular biocompatibility / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 433-437, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-354280
ABSTRACT
To prepare poly(lactic acid/glycolic acid/ asparagic acid-co- polyethylene glycol) (PLGA-[ASP-PEG]) and examine the cellular biocompatibility. PLGA-[ASP-PEG] was obtained by bulk ring-opening copolymerization method, examined by infrared spectrometry (IR) and 1H nuclear magnetic resonance spectroscopy (1H NMR). Bone marrow stromal cells(BMSCs) were cultured with PLGA-[ASP-PEG] (experiment gruop) and PLGA (control group) in vitro respectively, and were observed by phase-contrast microscopy and scanning electron microscopy. The resuls showed that PLGA-[ASP-PEG] was obtained and proved by IR and 1H NMR. The BMSCs of the experiment group could well attach to and extend on the surface of the PLGA-[ASP-PEG], and could proliferate and secrete better extracellular matrix, compared with control. The PLGA-[ASP-PEG] has good cellular a biocompatibility. It can be used as a biomaterial for bone tissue engineering.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyesters
/
Polyethylene Glycols
/
Polyglycolic Acid
/
Polymers
/
Biocompatible Materials
/
Bone Matrix
/
Chemistry
/
Aspartic Acid
/
Lactic Acid
/
Cell Biology
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2005
Type:
Article
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