The expression of the immediate early genes, c-fos, krox-24 and the late response gene, BKNF induced by antiepileptic drugs
Journal of the Korean Neurological Association
;
: 542-554, 1997.
Article
in Korean
| WPRIM
| ID: wpr-35431
ABSTRACT
The expression of the c-fos and krox-24 (immediate early genes IEGs) and the BDNF (late response gene) were investigated by convulsants such as kainate (KA, 200 micrometer), N-methyl-D-aspartate (NMDA, 10 mM), glutamate (GLU, 2 mM), and picrotoxin (PTX, 20 micrometer in the rat C6 glioma cells. In addition, the changes of their expression patterns were investigated by the anticonvulsants such as a NMDA antagonist MK-801, phenytoin, phenobarbiw, diazepam, and newer antiepileptic drugs like felbamate and gabapentin. NMDA induced c-fos and krox-24 expromiom were decreased spatially by the anticonvulsants. KA, NMDA, GLU, and PTX-induced BDNF expression were increased by the anticonvulsants. These results imply the molecular basis of the anticonvulsant action mechanism lies in differential and coordinated transcriptional regulation of IEGs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenytoin
/
Picrotoxin
/
Dizocilpine Maleate
/
N-Methylaspartate
/
Genes, Immediate-Early
/
Glutamic Acid
/
Brain-Derived Neurotrophic Factor
/
Convulsants
/
Diazepam
/
Glioma
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
1997
Type:
Article
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