A new cytotoxic metabolite from a deep sea derived fungus, Phialocephala sp

Li CHEN; De-hai LI; Sheng-xin CAI; Feng-ping WANG; Xiang XIAO; Qian-qun GU

A new cytotoxic metabolite from a deep sea derived fungus, Phialocephala sp / 药学学报

Li CHEN; De-hai LI; Sheng-xin CAI; Feng-ping WANG; Xiang XIAO; Qian-qun GU.

Acta Pharmaceutica Sinica ; (12): 1275-1278, 2010.

Article in English | WPRIM | ID: wpr-354527

ABSTRACT

ABSTRACT

A new sesquiterpene hydroquinone (1) was isolated from a deep sea sediment derived fungus, Phialocephala sp.. Its structure and stereochemistry were established on the basis of spectroscopic data and optical rotation. This compound was tested for cytotoxicity against P388 (murine leukemia cell) and K562 (human leukemia cell) cell lines, and displayed strong cytotoxic effects with IC50 value of 0.16 and 0.05 micromol x L(-1), separately.

Subject(s)

Animals; Humans; Mice; Antineoplastic Agents; Chemistry; Pharmacology; Ascomycota; Chemistry; Cell Line, Tumor; Cell Survival; Hydroquinones; Chemistry; Pharmacology; Inhibitory Concentration 50; K562 Cells; Leukemia P388; Pathology; Molecular Structure

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Ascomycota / Molecular Structure / Leukemia P388 / Cell Survival / Chemistry / K562 Cells / Inhibitory Concentration 50 / Cell Line, Tumor Limits: Animals / Humans Language: English Journal: Acta Pharmaceutica Sinica Year: 2010 Type: Article

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