UPLC-Q-TOF/MS analysis of naringin and naringenin and its metabolites in rat urine and feces after intragastric administration of alcohol extract of Exocarpium Citri grandis / 药学学报
Acta Pharmaceutica Sinica
; (12): 761-766, 2010.
Article
in Zh
| WPRIM
| ID: wpr-354536
Responsible library:
WPRO
ABSTRACT
To analyze naringin, naringenin and its metabolites in rat urine and feces after intragastric administration of alcohol extract of Exocarpium Citri Grandis, healthy SD rats were fed with alcohol extract of Exocarpium Citri Grandis for 3 days. On the last day, 0-24 h feces and 0-4 h, 4-8 h, 8-24 h urine were collected and analyzed by UPLC-Q-TOF/MS. The post-acquisition data were processed using Metabolynx The result is that naringin and its 6 metabolites, naringenin and its 4 metabolites were detected in the urine of rat. Meanwhile, naringin and its 3 metabolites, naringenin and its 2 metabolites were detected in the feces of rat.
Full text:
1
Index:
WPRIM
Main subject:
Plants, Medicinal
/
Urine
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Drugs, Chinese Herbal
/
Pharmacokinetics
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Random Allocation
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Chemistry
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Administration, Oral
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Chromatography, High Pressure Liquid
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Citrus
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Rats, Sprague-Dawley
Limits:
Animals
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article