Design, synthesis and antidepressive activity of duloxetine derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 869-873, 2010.
Article
in Zh
| WPRIM
| ID: wpr-354562
Responsible library:
WPRO
ABSTRACT
In this paper, duloxetine was chosen as the lead compound. The pharmacophores with 5-HT(1A) antagonism activity were used to replace the naphthyl of duloxetine. A series of duloxetine derivatives had been designed and synthesized and whose structures were confirmed with elemental analysis, MS and H NMR. All synthesized compounds were tested by tail suspension test and forced swimming test in vivo. The test results revealed that most of the compounds have shown better activity than duloxetine at the same dosage. Some of them are worth to be studied further.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Structure-Activity Relationship
/
Swimming
/
Thiophenes
/
Molecular Structure
/
Chemistry
/
Hindlimb Suspension
/
Serotonin 5-HT1 Receptor Antagonists
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Duloxetine Hydrochloride
/
Mice, Inbred ICR
Limits:
Animals
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article