Identification of main related substances in potassium sodium dehydroandrographolide succinate / 药学学报
Acta Pharmaceutica Sinica
;
(12): 641-646, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-354577
ABSTRACT
To identify the structure of three related substances in potassium sodium dehydroandrographolide succinate (PSDS), an HPLC preparation method was used to separate the impurities. These main impurities were identified using LC-ESI/TOFMS, LC-ESI/MSn, NMR, UV and IR. One of the main impurities was a hydrolyzed and oxidized product of PSDS, which has not been reported previouely. The other two impurities were hydrolyzed products of PSDS after losing different succinic acids. The results indicate that PSDS can be easily hydrolyzed and oxidized. It should be stored at cool and dry places.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Plants, Medicinal
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
/
Drug Contamination
/
Chromatography, High Pressure Liquid
/
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
/
Spectrometry, Mass, Electrospray Ionization
/
Andrographis
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article
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