Expressions and significance of B7-H1 and programmed death-1 in lymphocytes from patients with chronic hepatitis B virus infection / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 738-741, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-354645
ABSTRACT
<p><b>OBJECTIVE</b>To examine the expressions of B7-H1 and its receptor programmed death-1 (PD-1) on circulating T cells and myeloid dendritic cells (mDCs) in patients with chronic hepatitis B virus (HBV) infection and to investigate the correlation between their expressions and their disease status.</p><p><b>METHODS</b>The expressions of B7-H1 and PD-1 on mDCs and T lymphocytes in 30 patients with chronic HBV infection and 28 healthy controls were analyzed by a fluorescence-activated cell sorter (FACS). Real time-polymerase chain reaction (RT-PCR) was used to measure the serum HBV DNA load.</p><p><b>RESULTS</b>Both B7-H1 and PD-1 were significantly upregulated on T cells and mDCs in those patients. Their expressions were positively correlated with the patients serum ALT levels and HBV DNA loads.</p><p><b>CONCLUSION</b>B7-H1 and PD-1 expressions in our patients with chronic hepatitis B are closely associated with their disease status.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dendritic Cells
/
T-Lymphocytes
/
Antigens, CD
/
Case-Control Studies
/
Hepatitis B, Chronic
/
B7-H1 Antigen
/
Metabolism
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2007
Type:
Article
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