Detection of cytomegalovirus infection by polymerase chain reaction in hematopoietic stem cell transplantation recipients / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 407-409, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-354842
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the detection of cytomegalovirus (CMV) by polymerase chain reaction (PCR) for predicting the development of CMV disease.</p><p><b>METHODS</b>One hundred and thirty one allo-HSCT patients performed in the past 2 years were analyzed retrospectively. PCR-CMV was used to monitor CMV viremia and vireuria once a week after transplantation.</p><p><b>RESULTS</b>In the dynamic detection, CMV viremia was positive for at least one chance in 89 patients, vireuria did in 99 patients. Thirty-seven patients developed CMV disease with an accumulative incidence of 32.5%. The incidence of CMV disease was 15.6% in plasma CMV-PCR negative group, 31.3% in positive once group, and 47.3% in positive over twice group. There was significant difference among the three groups (P = 0.0126). The incidence of CMV disease was 24.8% in urine CMV-PCR negative group, 43.5% in positive once group, and 33.0% in positive over twice group, being no significant difference among them (P = 0.845). On analysis, viremia could predict the development of CMV disease the PPV (positive predictive value) is 40.5%, NPV (negative predictive value) is 84.4%, sensitivity is 75.0%, and specificity is 69.2%.</p><p><b>CONCLUSIONS</b>Detected by CMV-PCR, MCV viremia may predict the development of CMV disease, but MCV vireuria cannot.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation, Homologous
/
Urine
/
Blood
/
DNA, Viral
/
Polymerase Chain Reaction
/
Retrospective Studies
/
Sensitivity and Specificity
/
Cytomegalovirus Infections
/
Hematopoietic Stem Cell Transplantation
/
Cytomegalovirus
Type of study:
Diagnostic study
/
Observational study
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2003
Type:
Article
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