Study on autoimmune thrombocytopenic purpura related antibody / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 477-479, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-354848
ABSTRACT
<p><b>OBJECTIVE</b>To investigate a specific and sensitive assay for the diagnosis of autoimmune thrombocytopenic purpura (AITP).</p><p><b>METHODS</b>Glycoprotein specific autoantibodies in platelet eluate and plasma were detected by a modified monoclonal antibody immobilization of platelet antigens assay (MAIPA).</p><p><b>RESULTS</b>The overall positive rate of specific autoantibodies against platelet GPIIb/IIIa and GPIb/IX in plasma was 38.89% and in eluated platelet membrane was 68.52%. The difference between them was significant (corrected chi(2) = 19.39, P < 0.005). The proportion of positive MAIPA results between primary AITP and secondary AITP was not significantly different. There was a significant inverse correlation between antibody level and platelet count.</p><p><b>CONCLUSION</b>Detection of eluated GP-specific autoantibodies by MAIPA is highly specific and much more sensitive as compared with the measurement of their plasma counterparts in the diagnosing and therapeutic monitoring of AITP.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
Blood
/
Blood Platelets
/
Purpura, Thrombocytopenic, Idiopathic
/
Platelet Glycoprotein GPIIb-IIIa Complex
/
Platelet Glycoprotein GPIb-IX Complex
/
Allergy and Immunology
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2003
Type:
Article
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