Expression of costimulatory molecules on peripheral blood lymphocytes of patients with idiopathic thrombocytopenic purpura / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 474-476, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-354849
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of costimulators on peripheral T and B lymphocytes in patients with idiopathic thrombocytopenic purpura (ITP).</p><p><b>METHODS</b>The expression of B7-CD(28) and CD(40) of peripheral lymphocytes was measured by flow cytometry in 21 ITP patients and 9 normal subjects. The expression of PAIgG was measured by ELISA method.</p><p><b>RESULTS</b>The expression of CD(4)(+)CD(28)(+) was lower in ITP patients than in normal controls, but the expression of CD(86)(+) and CD(86)(+)CD(19)(+) was higher in ITP patients than in normal controls, while the expression of CD(80)(+), CD(40)(+), CD(28)(+), CD(19)(+)CD(86)(+), CD(19)(+)CD(40)(+), CD(4)(+)CD(28)(+)/CD(4)(+), CD(19)(+)CD(80)(+)/CD(19)(+) and CD(19)(+)CD(40)(+)/CD(19)(+) in ITP patients was normal. The PAIgG level was higher in 16 patients with a mean of (184.62 +/- 38.00) ng/10(7) plt. A positive correlation was found between PAIgG and CD(19)(+)CD(86)(+)/CD(19)(+) expression.</p><p><b>CONCLUSION</b>There is no deficiency in expression of CD(28) on CD(4)(+) T lymphocytes in ITP patients. The change of CD(86) expression on B lymphocytes is possibly involved in pathophysiology of ITP, which may provide a theoretical instruction for ITP patients immunological therapy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Blood Platelets
/
Immunoglobulin G
/
Lymphocyte Activation
/
Lymphocytes
/
Antigens, CD
/
Chemistry
/
Purpura, Thrombocytopenic, Idiopathic
/
Allergy and Immunology
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2003
Type:
Article
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