Expression of nm23 genes in acute myeloid leukemia and its clinical significance / 中华血液学杂志
Chinese Journal of Hematology
; (12): 369-371, 2003.
Article
in Zh
| WPRIM
| ID: wpr-354858
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore nm23 gene mRNA expression and its clinical significance in acute leukemias (AML).</p><p><b>METHODS</b>The levels of nm23-H1 and nm23-H2 transcripts in 22 patients with acute myeloid leukemia (AML), 9 AML in complete remission (AML-CR), 12 acute lymphoblastic leukemia (ALL) and 4 chronic myeloid leukemia in chronic phase (CML-CP) were assayed by reverse transcriptase-polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>The expression of nm23-H1 in AL especially in AML-M4 and AML-M5 was significantly higher than that in normal blood cells. An analysis of correlation between nm23 expression and clinicopathological parameters showed that increased nm23-H1 mRNA levels were associated with some poor-prognostic factors such as extramedullary infiltration, high white blood cell count (WBC), high lactate dehydrogenase (LDH) activity and high CD(7) expression, while inversely correlated with t(8; 21) and t(15; 17) which had a good-prognostic effect. The expression of nm23-H1 in AML patients in CR was significantly decreased compared with those untreated.</p><p><b>CONCLUSION</b>nm23-H1 was overexpressed in AL, especially in AML-M4 and AML-M5. High expression of nm23-H1 may be a poor prognostic factor.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
RNA, Messenger
/
Leukemia, Myeloid, Acute
/
Gene Expression
/
Nucleoside-Diphosphate Kinase
/
Reverse Transcriptase Polymerase Chain Reaction
/
NM23 Nucleoside Diphosphate Kinases
/
Genetics
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Hematology
Year:
2003
Type:
Article