Expression of SOX4 gene and early recurrence of hepatocellular carcinoma: their relationship and the clinical significance / 南方医科大学学报
Journal of Southern Medical University
;
(12): 818-819, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-355050
ABSTRACT
<p><b>OBJECTIVE</b>T To explore the relationship between the expression of SOX4 gene and early recurrence of hepatocellular carcinoma (HCC) after curative resection.</p><p><b>METHODS</b>SOX4 expression was detected immunohistochemically in 60 HCC patients including 30 with and 30 without early recurrence after curative resection, with 30 normal liver specimens as the control.</p><p><b>RESULTS</b>The expression of SOX4 was significantly higher in HCC than in normal liver (41.7% vs 16.7%, P<0.05), and in HCC tissues, the expression was significantly higher in early recurrent HCC after curative resection than in HCC without early recurrence (56.7% vs 26.7%, P<0.05). SOX4 expression was inversely correlated to the patients' gender, age, tumor size, HBsAg, and Edmonson grade (P<0.05).</p><p><b>CONCLUSION</b>SOX4 is closely associated with early recurrence of HCC after curative resection, and its overexpression may contribute to early recurrence of HCC. SOX4 may serve as a new molecular indicator for evaluating the prognosis of HCC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
General Surgery
/
Biomarkers, Tumor
/
Carcinoma, Hepatocellular
/
SOXC Transcription Factors
/
Genetics
/
Liver Neoplasms
/
Metabolism
/
Neoplasm Recurrence, Local
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article
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