Expression of cannabinoid receptor 2 in squamous cell carcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 593-595, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-355063
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of cannabinoid receptor 2 (CB2) in normal human skin and squamous cell carcinoma and analyze its relation with the tumorigenesis and development of squamous cell carcinoma.</p><p><b>METHODS</b>The expression of CB2 protein and mRNA levels were detected in normal human skin and squamous cell carcinoma using immunohistochemical staining and RT-PCR.</p><p><b>RESULTS</b>Both the normal skin and squamous cell carcinoma expressed CB2, which was localized mainly in the basal cell layer and prickle cell layer in human skin with low expressions in the subcutaneous tissue. The expression intensity of CB2 differed significantly between squamous cell carcinoma and normal human skin (P<0.05).</p><p><b>CONCLUSION</b>Squamous cell carcinoma over-expresses CB2 at both the protein and mRNA levels. High expression of CB2 in squamous cell carcinoma suggests an important role of CB2 in the tumorigenesis and development of squamous cell carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Skin Neoplasms
/
RNA, Messenger
/
Carcinoma, Squamous Cell
/
Reverse Transcriptase Polymerase Chain Reaction
/
Receptor, Cannabinoid, CB2
/
Genetics
/
Metabolism
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article
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