Effect of levonorgestrel-releasing intrauterine system combined with GnRH analogue for treatment of large adenomyosis / 南方医科大学学报
Journal of Southern Medical University
; (12): 541-546, 2010.
Article
in Zh
| WPRIM
| ID: wpr-355078
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of levonorgestrel-releasing intrauterine system (LNG-IUS) combined with GnRH analogue (GnRH-a) in the treatment of adenomyosis with uterine body enlargement.</p><p><b>METHODS</b>Twelve women (mane age 40.3 years) with adenomyosis and uterine cavity depth over 11 cm received injections of GnRH-a every 4 weeks, and after the uterine cavity depth was reduced to below 10 cm, LNG-IUS was deployed. VAS pain score, PBAC bleeding score, uterine volume, and hemoglobin levels of the women were measured before the treatment and at 6 and 12 months after LNG-IUS placement.</p><p><b>RESULTS</b>The VAS pain score was significantly lowered at 6 and 12 month after LNG-IUS placement (P<0.05), and the PBAC bleeding score also showed significant reductions (P<0.05). The uterine volume decreased significantly at 6 and 12 months after LNG-IUS placement as compared with that before the treatment, but was significantly greater at 6 month in comparison with that at the time of LNG-IUS placement (P<0.05). Serum hemoglobin levels underwent significant increments after LNG-IUS placement (P<0.05).</p><p><b>CONCLUSION</b>LNG-IUS combined with GnRH analogue injection can be effective in the treatment of adenomyosis with dysmenorrhea and hypermenorrhea.</p>
Full text:
1
Index:
WPRIM
Main subject:
Uterine Diseases
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Gonadotropin-Releasing Hormone
/
Levonorgestrel
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Delayed-Action Preparations
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Therapeutic Uses
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Drug Therapy
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Drug Therapy, Combination
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Endometriosis
Limits:
Adult
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Female
/
Humans
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article