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Autologous skeletal myoblast transplantation improves hemodynamics dogs with chronic heart failure dogs / 南方医科大学学报
Journal of Southern Medical University ; (12): 475-477, 2010.
Article in Chinese | WPRIM | ID: wpr-355097
ABSTRACT
<p><b>OBJECTIVE</b>To test the effects of autologous skeletal myoblast transplantation on the hemodynamics in dogs with coronary microembolization-induced chronic heart failure (CHF).</p><p><b>METHODS</b>CHF models were successfully induced in 19 dogs and divided into ASMT group (n=9) and control group (n=10). The myoblasts were injected into the embolized region in the 9 dogs of the ASMT group, and saline was injected in the control dogs, and the hemodynamics of the dogs were evaluated 5 weeks after the injections.</p><p><b>RESULT</b>Compared with saline injection, ASMT significantly increased dP/dtmax, MAP and LVSP (P<0.05) and decreased LVEDP (P<0.05) 5 weeks after myoblast transplantation. Desmin and Brd-U immunofluorescent staining showed myoblast survival at the injected sites in the dogs.</p><p><b>CONCLUSION</b>ASMT provides mild improvements in the hemodynamics of dogs with CHF.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Therapeutics / Transplantation / Transplantation, Autologous / Chronic Disease / Myoblasts, Skeletal / Heart Failure / Hemodynamics Limits: Animals Language: Chinese Journal: Journal of Southern Medical University Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Therapeutics / Transplantation / Transplantation, Autologous / Chronic Disease / Myoblasts, Skeletal / Heart Failure / Hemodynamics Limits: Animals Language: Chinese Journal: Journal of Southern Medical University Year: 2010 Type: Article