Significance of serum CD62p and CD63 levels in patients with head injury / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 562-565, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-355161
ABSTRACT
<p><b>OBJECTIVE</b>To determine the serum levels of CD62p (alpha-granular membrane protein) and CD63 (lysosome intact membrane protein) in patients with head injury and to observe its relation to injury severity.</p><p><b>METHODS</b>Fifty-three patients with head injury were divided into 3 groups; Group A patients with mild head injury; Group B with moderate head injury; and Group C with severe head injury. The serum levels of CD62p, CD63 were measured on 12 h, d 1, 3, 5 and 7 after injury.</p><p><b>RESULT</b>The serum levels of CD62p and CD63 in Group B and Group C were higher than those in Group A and control (P<0.05). The serum level of CD62p in Group C was higher than that in Group B (P<0.05). The serum levels of CD62p in Group C on d 1, 3, 5 after injury were higher than those on 12 h (P<0.05). The serum level of CD63 in Group B on d 3 after injury were higher than that on 12 h (P<0.05). The serum levels of CD63 in Group C on d 1, 3, 5 after injury were higher than those on 12 h (P<0.05).</p><p><b>CONCLUSION</b>The serum levels of CD62p and CD63 in patients with head injury may be helpful for identifying the severity of injury, and CD62p seems to be more sensitive.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Blood Platelets
/
Brain Injuries
/
Platelet Membrane Glycoproteins
/
Antigens, CD
/
Platelet Activation
/
Trauma Severity Indices
/
P-Selectin
/
Tetraspanin 30
/
Metabolism
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2005
Type:
Article
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