Expression of MMP-2 and E-CD in salivary mucoepidermoid carcinoma and its correlation with infiltration, metastasis and prognosis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 421-426, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-355191
ABSTRACT
<p><b>OBJECTIVE</b>To study the expressions of matrix metalloproteinase 2 (MMP2) and E-cadherin (E-CD) in salivary mucoepidermoid carcinoma, and their relationship with clinical stages, pathological grading, lymph node metastasis and prognosis.</p><p><b>METHODS</b>Surgical specimens of salivary mucoepidermiod carcinoma and normal salivary gland tissue were collected. MMP-2 and E-CD were stained immunohistochemically with streptavidin peroxidase method.</p><p><b>RESULTS</b>The expression of MMP-2 was increased and the expression of E-CD was reduced or negative in salivary mucoepidemoid carcinoma compared with those of the normal salivary gland. Expression of MMP-2 and E-CD was closely correlated with lymph node metastasis of the mucoepidermoid carcinoma. MMP-2 was positively correlated with the prognosis of mucoepidermoid carcinoma, and E-CD was negatively correlated to the prognosis of mucoepidermoid carcinoma.</p><p><b>CONCLUSION</b>The expression of MMP-2 and E-CD is closely correlated with the metastasis and prognosis of salivary mucoepidermoid carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Salivary Gland Neoplasms
/
Cadherins
/
Carcinoma, Mucoepidermoid
/
Matrix Metalloproteinase 2
/
Genetics
/
Metabolism
/
Neoplasm Invasiveness
/
Neoplasm Metastasis
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2005
Type:
Article
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