Comparison of methods to detect insulin resistance in obese children and adolescents / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 316-319, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-355214
ABSTRACT
<p><b>OBJECTIVE</b>To explore the practical and sensitive index for insulin resistance in obese children and adolescents.</p><p><b>METHODS</b>An oral glucose tolerance test and insulin releasing test were performed in 126 obese (divided into 3 groups according their BMI) and 25 normal children. The ratio of fasting plasma glucose to fasting plasma insulin (FBG/FINS), homeostasis model assessment-insulin resistance (HOMA-IR), homeostasis model assessment-insulin activity index (IAI), whole body insulin sensitivity index (WBISI) and area under curve of glucose and insulin (AUCBG, AUCINS) were calculated.</p><p><b>RESULT</b>There were no significant differences in fasting plasma glucose levels, while significant differences existed in fasting plasma insulin, the ratio of fasting plasma glucose to fasting plasma insulin,homeostasis model assessment-insulin resistance, homeostasis model assessment-insulin activity index, whole body insulin sensitivity index, area under curve of glucose, area under curve of insulin and AUCINS/AUCBG among these four groups. Whole body insulin sensitivity index (WBISI) reflected the sensitiveness of the insulin earlier than that of homeostasis model assessment-insulin resistance and homeostasis model assessment-insulin activity index.</p><p><b>CONCLUSION</b>Whole body insulin sensitivity index seems to be a better index for insulin resistance for obese children.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Blood Glucose
/
Insulin Resistance
/
Sensitivity and Specificity
/
Glucose Tolerance Test
/
Insulin
/
Methods
/
Obesity
Type of study:
Diagnostic study
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2005
Type:
Article
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