Ultrastructure and crystallin mutant molecular modeling of hereditary coralliform cataract / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 243-247, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-355232
ABSTRACT
<p><b>OBJECTIVE</b>To observe the correlation of gammaD-crystallin P23T mutant with lens ultrastructure of the hereditary coralliform cataract.</p><p><b>METHODS</b>Complete ophthalmologic examinations were performed before lens extraction and lens samples were studied by transmission and scanning electric microscope respectively. Protein molecular modeling was performed using SWISS-MODEL(version 2.0).</p><p><b>RESULTS</b>Protein structure modeling demonstrated that the mutant caused a decrease in molecular final total energy and changes in the surface structure of gammaD-crystallin. Ultrastructure study revealed crystals deposited in lens, extensive granules dispersed in uncommon oval structure and the disorganization of lens epithelial cells.</p><p><b>CONCLUSION</b>It is possible that the gammaD-crystallin P23T mutant is associated with abnormal crystals in lens and disorganization of lens epithelial cells.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pedigree
/
Phenotype
/
Cataract
/
Point Mutation
/
Gamma-Crystallins
/
Genetics
/
Lens, Crystalline
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2005
Type:
Article
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