Effect of Radix euphorbiae pekinensis extract on bioavailability of paclitaxel after their oral co-administration / 南方医科大学学报
Journal of Southern Medical University
;
(12): 916-921, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-355257
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of Radix euphorbiae pekinensis extract on the permeability and bioavailability of paclitaxel co-administered orally.</p><p><b>METHODS</b>Based on Ussing Chamber and in vivo experiment, the permeability and bioavailability of paclitaxel were evaluated after oral co-administration with radix euphorbiae pekinensis in rats. The contents of paclitaxel in the permeates and the blood samples were determined using HPLC and LC-MS/MS method, respectively.</p><p><b>RESULTS</b>In Radix euphorbiae pekinensis co-administration group, the Papp of the mucosal-to-serosal (M-S) transport or serosal-to-mucosal transport (S-M) of paclitaxel in the jejunum or ileum segment differed significantly from those in verapamil co-administration group and blank control group (P<0.05), but the Papp of S-M transport in the colon showed no significant difference from that in the blank control group. In the blank group, the average absolute bioavailability (AB%) of orally administered paclitaxel was only 2.81%, compared to that of 7.63% in radix euphorbiae pekinensis group. The average AB% in verapamil group was about 1.5 times that of the blank group.</p><p><b>CONCLUSION</b>Co-administration of Radix euphorbiae pekinensis extract can increase the bioavailability of orally administered paclitaxel.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Pharmacology
/
Biological Transport
/
Pharmacokinetics
/
Plant Extracts
/
Biological Availability
/
Verapamil
/
Chemistry
/
Administration, Oral
/
Chromatography, High Pressure Liquid
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2015
Type:
Article
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