Preparation and performance of pravastatin sodium-loaded chitosan microspheres / 南方医科大学学报
Journal of Southern Medical University
;
(12): 879-882, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-355265
ABSTRACT
<p><b>OBJECTIVE</b>To prepare pravastatin sodium-loaded chitosan microspheres to allow sustained drug release.</p><p><b>METHODS</b>The drug-loaded chitosan microspheres were prepared by using genipin as the cross-linker. The influences of molecular weight of chitosan, volume ratio of oil and water, reaction temperature, and stirring speed on the formation of chitosan microspheres were investigated. The morphology of the microspheres was observed using scanning electron microscopy. The encapsulation efficiency, swelling ratio under different pH conditions, and in vitro drug release were measured.</p><p><b>RESULTS</b>The in vitro release of pravastatin sodium could last for at least 31 days. The drug release rate varied with the reaction condition. The drug entrapment efficiency of the microsphere was 54.7%. The optimal processing conditions were as follows chitosan viscosity of 200-400 mPa·s, oil-water proportion of 101, stirring speed of 850 r/min, and reaction temperature at 40 degrees celsius;.</p><p><b>CONCLUSION</b>The pravastatin sodium-loaded microspheres show good sustained drug release property, and the drug release rate can be modified by controlling the cross-linking time.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Microscopy, Electron, Scanning
/
Chemistry
/
Pravastatin
/
Cross-Linking Reagents
/
Delayed-Action Preparations
/
Iridoids
/
Chitosan
/
Microspheres
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2015
Type:
Article
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